The motor cortex has been implicated also in the origin of psychomotor abnormalities present in psychiatric disorders including schizophrenia as a consequence of the abnormal modulation of the motor cortex activity caused by misbalanced activity coming from subcortical structures (Northoff et al., 2021); therefore, a detailed understanding of the alterations of the primary motor cortex caused by Lis1 dysfunction could contribute to clarify the pathophysiology of lissencephaly and other brain diseases. This evidence concerns the gene PAFAH1B1 and Lissencephaly.