PAFAH1B1 and lissencephaly spectrum disorders: The motor cortex has been implicated also in the origin of psychomotor abnormalities present in psychiatric disorders including schizophrenia as a consequence of the abnormal modulation of the motor cortex activity caused by misbalanced activity coming from subcortical structures (Northoff et al., 2021); therefore, a detailed understanding of the alterations of the primary motor cortex caused by Lis1 dysfunction could contribute to clarify the pathophysiology of lissencephaly and other brain diseases.