The possibility that different LIS1 alterations may produce different pathologies is highly relevant since some authors have proposed that alterations in some portions of the gene encoding for LIS1 may be implicated in neurological disorders less severe than lissencephaly, such as schizophrenia, autism, and bipolar disorder (Reiner et al., 2006; Tabares-Seisdedos et al., 2006; Tabares-Seisdedos et al., 2008). The gene discussed is PAFAH1B1; the disease is Lissencephaly.