On the one hand, the increase of mTOR activity led to the augment of Gli2 transcription factor in the Hh signaling pathway; on the other hand, the Hh signaling pathway positively regulated mTOR complex 1 (mTORC1) activity by up-regulating the homeodomain protein NK2 homeobox 2 (NKX2.2), creating a vicious circle between the two pathways to accelerate cancer progression (Klein et al., 2019; Larsen and Møller, 2020). This evidence concerns the gene NKX2-2 and cancer.