For example, in gastric cancer cells, OTUB2 can deubiquitinate the lysine specific demethylase 1A (KDM1A, not only can demethylate histones, but also p53, DNA methyltransferase, etc.)to promote gastric cancer cell proliferation, migration, and invasion (Huang et al., 2007; Lan et al., 2008; Wang et al., 2009; Liu et al., 2021). Here, TP53 is linked to gastric cancer.