Based on the above functions of TRAF6 in the NF-kappaB pathway, Ma et al. proposed that OTUB2 in thyroid cancer could guide the deubiquitination of TRAF6 and promote the activation of the NF-kappaB pathway, which seemed to be consistent with previous work (Li et al., 2010; Ma and Sun, 2019). This evidence concerns the gene OTUB2 and thyroid gland carcinoma.