The five miRNAs in our study have also been identified as crucial mediators of CRC, and all of them were downregulated in CRC, while only miR-365a-3p and miR-375 have been confirmed to directly suppress NF-κB activation (Sun et al., 2018; Yin et al., 2019). The gene discussed is NFKB1; the disease is colorectal carcinoma.