In CRC, a number of studies have confirmed that some molecules, such as MyD88, SREBP1, and CXCL5, promoted CRC cell proliferation, migration, invasion, and tumor growth through NF-κB activation (Chen et al., 2019; Gao et al., 2019; Zhu et al., 2020). The gene discussed is CXCL5; the disease is neoplasm.