These subtypes, ranging from tumor progression to tumor suppression, respectively, were named as C1 (wound healing), C2 (INF-g dominant), C3 (inflammatory), C4 (lymphocyte depleted), C5 (immunologically quiet), and C6 (TGF-b dominant) (Tamborero et al., 2018). This evidence concerns the gene TGFB1 and neoplasm.