JAM3 and famililal cerebral cavernous malformations: Interestingly, gene mutations in endothelial junctional proteins occludin, junctional adhesion molecule 3 (JAM3) and cerebral cavernous malformation (CCM) −1, −2, −3 lead to the BBB deficiency and brain calcification (Saitou et al., 2000; Mochida et al., 2010; O’driscoll et al., 2010; Fischer et al., 2013).