Patients with Nasu-Hakola disease, a neurodegenerative disease caused by mutations in TYRO protein tyrosine kinase-binding protein (TYROBP, also known as DAP12) or TREM2, present with cerebrovascular changes and bilateral basal ganglia calcifications localized to the walls of blood vessels (Kalimo et al., 1994; Coomans et al., 2018). The gene discussed is TYROBP; the disease is Nasu-Hakola disease.