CASP3 and malignant colon neoplasm: Genistein has been shown to induce apoptosis via the activation of caspase-9 and caspase-3 in HeLa human cervical cancer cell line [92], inhibition of the NF-ĸB pathway and regulation of caspase-3 and p38 MAPK signalling pathway in HT-29 human colon cancer cell line [93,94].