Immunohistochemistry for LEPR revealed a high propensity (8/9) for high‐grade osteosarcomas to be LEPR+, whereas low‐grade tumors displayed a lower rate of LEPR positivity (2/7) (p = 0.01; Fig. 2A–C) with signal predominantly and most intensely in tumor fibroblasts. Here, LEPR is linked to neoplasm.