LEPR and neoplasm: Although a small subset of LEPR cells have been reported to be periosteal stem/progenitor cells in the outer layer of the periosteum, the general lack of LEPR expression in low‐grade parosteal tumors suggests that there may be another periosteal progenitor population driving oncogenesis.(24) However, as an important limitation of the specimen cohort studied here, low tumor grade and periosteal anatomic location co‐occurred, making it not possible to disentangle the effects of these parameters on the rate of positivity for CAR cell–associated markers.