It was also shown that the introduction of Tet2 deletion in the Sf3b1-K700E model19 and Runx1 deletion in the U2af1-S34F model17 more accurately mirrored the MDS phenotype, shedding some light on how SF mutations co-operate with other frequently co-occurring mutations. The gene discussed is U2AF1; the disease is myelodysplastic syndrome.