U2AF1 and myelodysplastic syndrome: For example, aberrant splicing of the iron transporter ABCB7 (in SF3B1-mutant cases),12EZH2 (in SRSF2-mutant cases),13 and STRAP and H2AFY (in U2AF1-mutant cases)14 has been linked to some of the hematological abnormalities found in MDS.2