PDCD1 and neoplasm: As a consequence, there is a decrease in the activation of the transcription factors AP-1, NFAT, and NF-kB; reducing the activation, proliferation, survival, and production of cytokines in the T lymphocyte.4▪ mAbs that block PD-1 activity induce a cytokine cross-talk between the PD-1+ T cells and the dendritic cells specialized in cross-priming in the tumor microenvironment.5