DNASE1L3 and cardiac hypertrophy: In support of the latter is our previous findings of reduced vascular perfusion of kidney and heart in PyMT+ mice compared to healthy littermates, which was reverted upon removal of NETs by DNase I treatment.19 Interestingly, a very recent study (published during revision of this manuscript) reports that NETs can cause immunothrombosis in the small vessels of the myocardium, leading to cardiac hypertrophy and dysfunction in a mouse model of angiotensin II-cardiomyopathy.60 DNase I treatment for 3 days did not affect the functional parameters measured by echocardiography in our study.