Genetic ablation of these two DNases in mouse resulted in accumulation of intravascular NETs and clot formation, which obstructed blood vessels and caused organ damage.62 In addition, DNase I is already in clinical use for the management of cystic fibrosis since decades, demonstrating its safety as a drug in this context.63 In cystic fibrosis patients, debris containing extracellular DNA is accumulating in the airways and DNase I in the form of an aerosol spray relieves the respiratory symptoms. The gene discussed is DNASE1L3; the disease is cystic fibrosis.