Increased levels of soluble TNF-receptors (sTNFRs) were also detected in plasma from cancer patients and has been associated with cardiovascular disease in several studies.49 A correlation between TNFα and H3Cit levels in plasma from cancer patients were also reported, supporting the connection between NETs and inflammation.45 There is in fact an intricate interplay between NETs and inflammation. Here, TNF is linked to cardiovascular disorder.