SLC1A2 and depressive disorder: GLT1 inhibition is known to induce depression-like behaviors (Bechtholt-Gompf et al., 2010), whereas upregulation of GLT1 can have an antidepressant effect (Rothstein et al., 2005; Sanacora et al., 2007; Bechtholt-Gompf et al., 2010; Ding et al., 2017).