HCAR2 and atherosclerosis: Its specific binding can activate the adipocyte-expressed GPCRs, HM74a/PUMA-G, to reduce lipolysis in adipocytes and regulate fatty acid availability and metabolism (Tunaru et al., 2003; Taggart et al., 2005), which may have anti-atherosclerosis and anti-inflammatory effects (Lukasova et al., 2011).