By integrated analysis of the genomic, transcriptomic, and clinical data from the Chinese Glioma Genome Atlas (CGGA), The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Rembrandt and Gravendeel datasets, we found that the RNA and protein of BIRC5 were significantly up-regulation in LGG tissue, high level of BIRC5 was correlated with tumor grade and poor prognosis in LGG. The gene discussed is BIRC5; the disease is central nervous system cancer.