Functional, pathway, and gene network analyses revealed significant biological functions, including cancer, cell cycle, cellular movement, molecular transport, and RNA trafficking, as well as several key genes and cancer-related pathways that may have importance for NSCLC transformation, including FAM83A, ZNF696, UBE2C, RECK, TIMM50, GEMIN7, and XPO5. Indeed, some of the identified genes were reported to be associated with cancers, including lung cancer. This evidence concerns the gene RECK and cancer.