Additionally, this model suggests a pathogenic role in FasL-mediated T cell differentiation in the development of Type 1 diabetes, as shown in the NOD mice model by Xiao, et al. (58, 59) In NOD mice, CD8+ T-cells have been shown to exert β-cell destruction, which can be abrogated with FasL blockade, which would reduce CD8+ effector differentiation and function (11, 58, 59). This evidence concerns the gene FASLG and type 1 diabetes mellitus.