MAPT and early-onset autosomal dominant Alzheimer disease: Nevertheless, total tau protein concentrations in CSF correlated with the cognitive status reflected by the MMSE score in 4 of the 5 large datasets from the longitudinal ADNI studies (The Alzheimer’s Disease Neuroimaging Initiative), INDD (The Integrated Neurodegenerative Disease Database), and CBAS (The Czech Brain Aging Study) as well as the DESCRIPA cross-sectional study (Development of Screening Guidelines and Criteria for Predementia Alzheimer’s Disease) that were analyzed by the Global Alzheimer’s Association Interactive Network (GAAIN) database (25).