Total tau protein values correlated with the yearly (r = 0.56, p < 0.005; Figure 3A) and long-term cognitive decline in both groups (MMSE difference in follow-up compared to MMSE baseline) when investigated as a single group (r = 0.38, p < 0.05; Figure 3B) (AD and NABD+: n = 27), but not when subgroups (AD or NABD+) were investigated separately. The gene discussed is MAPT; the disease is Alzheimer disease.