TNF and septic peritonitis: As expected, both PLF and plasma levels of TNFα and IL-6 were increased in the setting of septic peritonitis, which was inhibited significantly by GTS-21(Figure 1B), In addition, mice subjected to CLP showed histopathological evidence of organ injuries, including thickening of the alveolar septa and interstitial edema in lung sections, and swelling of hepatocytes and massive infiltration of neutrophils in liver sections, and GTS-21 treated mice showed a marked reduction in these septic-related organ injuries (Figure 1C).