Based on these results, OPN may act as a trigger to further accelerate the inflammation of CRSwNP in the early stage and to induce the formation of nasal polyp through the induction of irreversible tissue remodeling in the nasal cavity We plan to further investigate the effect of OPN in an eosinophilic mouse model made with Staphylococcal enterotoxin B (SEB) and OVA. This evidence concerns the gene SETBP1 and chronic rhinosinusitis with nasal polyps.