CD4 and experimental autoimmune encephalomyelitis: Diminished CD4+ T cell stimulation in the absence of LAP supported MHC class II restricted antigen presentation by dendritic cells leads also to an amelioration of experimental autoimmune encephalomyelitis (EAE), an autoimmune CNS disease in mice, after adoptive transfer of autoimmune CD4+ T cells into mice that are either deficient in ATG5 or NOX2 (43, 59, 60).