IFNG and psoriasis: Cells within a single CD8 TEM cluster enriched among PSO subjects (cluster 11, Figure 3B) showed a strong upregulation of CCL4, a CD8+ T cell recruiting (29) chemokine associated with psoriasis (30), along with other inflammatory cytokines and chemokines (TNF, IFNG, CCL3, CCL4L2) (Figure 3C and Supplementary Table 5).