TNFAIP3 and rheumatoid arthritis: Among PSA T and NK cells, we also observed a downregulation of AP-1 transcription factors (JUN, JUNB, JUND, FOS) and regulators of activation (TNFAIP3, DUSP1) along with the upregulation of S100A11, a calcium-binding protein associated with rheumatoid arthritis (19).