While, to our knowledge, the role of dnTs and HSPCs in PSA has not been extensively investigated, dnT cells have been reported to infiltrate psoriatic skin as well as participate in IL-23/IL-17 signaling in mouse models of psoriasis (34) and spondyloarthritis (35), and the proliferation and differentiation of HSPCs is currently known to respond to systemic interferon and TNF signaling (36). The gene discussed is TNF; the disease is spondyloarthropathy.