Cells within a single CD8 TEM cluster enriched among PSO subjects (cluster 11, Figure 3B) showed a strong upregulation of CCL4, a CD8+ T cell recruiting (29) chemokine associated with psoriasis (30), along with other inflammatory cytokines and chemokines (TNF, IFNG, CCL3, CCL4L2) (Figure 3C and Supplementary Table 5). Here, TNF is linked to psoriasis.