For instance, it can regulate NF-κB and provides neuroprotection by suppressing pro-inflammatory cytokines TNF-α and IL-1β in AD brain, downregulate IL-6 and IL-17 expression in rheumatoid arthritis mice model, or suppress microgliosis and inflammatory cytokine production in the optic nerve of experimental autoimmune encephalomyelitis model (48, 96–98). This evidence concerns the gene TNF and experimental autoimmune encephalomyelitis.