In this regard, Pepys et al. first demonstrated that 1, 6-bis(phosphocholine)-hexane was a small molecule capable of binding in a ration of 5:2 with individual sub-units of CRP; on binding, and applied to a rat model of myocardial infarction, both myocardial infarction volume and cardiac dysfunction were abrogated (32). Here, CRP is linked to myocardial infarction.