IL6 and Sepsis: The plasma from a group of patients with sepsis, showed significantly higher levels of EVs bound to mCRP associated with enhanced IL-8 secretion compared with healthy individuals indicating a direct mechanism for perpetuation of the condition, whilst apheresis and removal of the mCRP was sufficient to reduce circulating cytokine levels (24); whilst, in autoimmune diseases such as lupus nephritis, highest levels of mCRP-antibodies in the serum was associated with worse symptomatic disease, increased expression of IL-6 and TNF-α, and clinical evidence of systemic lupus erythematosus (25).