The study included data from 81 IEI patients (median age 35 years) including six allo-HCT recipients for IEI and 75 patients with ongoing IEI (including 26 patients with STAT3 dominant negative mutations, 14 with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), seven with CVID, five with hypogammaglobulinemia, and four with warts-hypogammaglobulinemia-infections-myelokathexis (WHIM) syndrome) mostly immunized with mRNA vaccine. Here, STAT3 is linked to agammaglobulinemia.