MAPT and dementia: Elevated levels of peripheral systemic LPS or peripheral pro-inflammatory cytokines result in transient neuronal death, and systemic LPS exposure does result in increased deposition of Aβ 1-42 and phosphorylated tau (p-tau) levels in the wild-type rodent brain; thus these pathological changes directly or indirectly induce synaptic and neuronal dysfunction and ultimately lead to clinical dementia (70, 72).