Researchers detected more than 30 modified acetylation sites in histones (H1, H2A, H2B, H3.3, and H4) in GBM, and further differential analysis showed that two acetylation sites were significantly upregulated in H4 histones and 25 acetylation sites were significantly downregulated in H2B histones (Supplementary Table S14). This evidence concerns the gene H2BC21 and glioblastoma.