Second, RA patient CD4+ T cells exhibit hypermethylated genes, including JUN, STAT1, PTEN, and CD44, compared to healthy controls, whereas hypomethylated genes include KRAS and ALB. Additionally, the expression levels of STAT5B, SOCS3, JUN, STAT1, KRAS, ALB, and CD44 were increased in RA. This evidence concerns the gene JUN and rheumatoid arthritis.