In gliomas, the transcription factor AP-4 can bind to the LINC00520 promoter region and activate the transcription of LINC00520, while miR-520f-3p can inhibit the expression of TFAP4, forming a TFAP4/LINC00520/miR-520f-3p/TFAP4 feedback loop, thereby regulating the malignant biological behavior of glioma cells (9). Here, TFAP4 is linked to central nervous system cancer.