The LINC00520/miR-195/HOXA10 axis can up-regulate the expression of invasion and migration factors (MMP2 and MMP9) and anti-apoptotic factor Bcl-2, and down-regulate the expression of apoptotic factor Bax, which ultimately promotes cell proliferation, invasion, and metastasis of HNSCC (19). This evidence concerns the gene LINC00520 and head and neck squamous cell carcinoma.