ZFAS1 regulates the activity of small nucleolar RNA-induced rRNA 2’-O-methylation through a ZFAS1-NOP58-SNORD12C/78-EIF4A3/LAMC2 signaling-dependent manner, thus promoting the proliferation and migration of colorectal cancer (CRC) cells (12). This evidence concerns the gene ZFAS1 and colorectal carcinoma.