TRDMT1 and neoplasm: As a result, DNMT3A, DNMT3B, ALYREF, NSUN3, NSUN6, NSUN7, and TET2 were significantly up-regulated in tumor samples (p < 0.05), and NOP2, NSUN2, NSUN4, NSUN5, and DNMT1 regulators were significantly down-regulated (p < 0.05), while TRDMT1 was the only regulator without significant change in expression (p = 0.276) (Figure 1A).