In addition, the effects of lncRNAs on the tumor microenvironment (TME) have been widely reported, for example, high expression of LNC-EGFR in liver cancer binds to EGFR, stabilizes and maintains the RAS/ERK/AP1 signaling pathway, leading to Treg differentiation, cytotoxic T lymphocyte (CTL) suppression (14). This evidence concerns the gene EGFR and liver cancer.