RAG1 and neoplasm: To address this, we took advantage of a murine model of Group 3 medulloblastoma that engrafts in C57Bl/6J mice following intracranial implantation and compared tumor growth in wildtype C57Bl/6J mice and C57Bl/6J mice deficient in Rag1. Tumor-free survival of control mice (sham/isoflurane or control/saline) was not different between WT and Rag1KO animals, indicating that growth of this model of Group 3 medulloblastoma is not impacted by the presence or absence of mature T and B cells (Figure 1).