Eculizumab, a monoclonal antibody that inhibits the cleavage of C5 to C5a and C5b and previously approved for treatment of paroxysmal nocturnal hematuria (71) and atypical hemolytic uremic syndrome (72), is also currently in a clinical trial to investigate its efficacy in severe COVID-19 (ClinicalTrials.gov Identifier: NCT04355494). This evidence concerns the gene C5 and atypical hemolytic-uremic syndrome.