The expression of LncRNA XIST in CD4+ T cells and NK cells were significantly higher in PBC patients than that in HC (1.26 ± 0.09 vs 0.48 ± 0.19, 1.19 ± 1.23 vs 0.34 ± 0.31, p<0.01 and p<0.05). This evidence concerns the gene CD4 and primary biliary cholangitis.