IL6 and hepatocellular carcinoma: In murine models of hepatocellular carcinoma, TLR2-deficient mice showed a decrease in the expression of IFN-γ, TNF-α, (IL)-1α/β, IL-6, and Cxcl-2, which attenuate p21- and p16/pRb-dependent senescence, leading to the increased proliferation of tumor cells (222).