For example, in a mouse model of PC liver metastasis, IL-6 derived from activated macrophages activates the oncogenic transcription factor STAT3, which directly inhibits the miR-124 gene through its conserved STAT3 binding site in its promoter; targeting Notch ligand Jagged 1 to regulate Notch signaling in cancer cells, thereby promoting mesenchymal transition and invasion (101). Here, STAT3 is linked to pachyonychia congenita.