Therefore, the ability of CLL cells to present particulate Ag may be important for pathogenesis, especially as some CLL BCRs can recognize Ag/autoantigens (including viruses, bacteria, fungi and apoptotic cell fragments) which may be encountered in a particulate form in vivo [19–24] and particulate Ag may engage T-cell help more effectively than soluble Ag. The gene discussed is RENBP; the disease is B-cell chronic lymphocytic leukemia.