For example, variants in protein kinase AMP-activated non-catalytic subunit gamma 2 (PRKAG2) has been identified as causative of familial Wolff-Parkinson-White Syndrome (Miyamoto 2018), but no CCS-related annotations are associated with this gene, even though these patients exhibit short PR interval, prolonged QRS and have ectopic conductive atrioventricular (accessory) pathways. This evidence concerns the gene PRKAG2 and Wolff-Parkinson-White syndrome.