For DEMs, CRNKL1 was up-regulated in IDD patients in these three datasets with no significant difference (Figures 8A–C); PDGFRB was up-regulated in IDD patients in GSE150408 (Figure 8D) and GSE153761 (Figure 8E) datasets with no significant difference; IL1R1 had a trend of significant up-regulation in IDD patients in GSE124272 (Figure 8F); and CXCL12 (Figures 8H,I) was up-regulated in both GSE124272 and GSE153761 datasets with no significant difference. Here, CRNKL1 is linked to intervertebral disk degenerative disorder.