SCN3B and early-onset autosomal dominant Alzheimer disease: Pathological levels (both increase and decrease) of SCN3B mRNA have been implicated in multiple neurodegenerative diseases such as amyotrophic lateral sclerosis and Alzheimer’s disease as well as cancer (Adachi et al., 2004; Dunckley et al., 2006; Nutini et al., 2011).