Hypermethylation of KIBRA, DLEC1, FAT4, WT1, H19, MALAT1, APC, ACIN1, BCL2, CD44, TNFRSF10C and RARB promoters in peripheral blood leukocytes was found to be statistically significant in GC patients (Dauksa et al., 2014; Hu D. et al., 2021; Sun et al., 2018; Xie et al., 2020; Zhang et al., 2018; Zhou et al., 2019). Here, APC is linked to gastric cancer.