FOXO1 and Familial prostate cancer: The anti-proliferative role of FOXO1 has been reported in case of cervical and prostate cancer, moreover, the enforced expression of FOXO1 in endometrioid endometrial cancer cells and SiHa cells blocked the cell proliferation and decreased the tumorigenic activity (Goto et al., 2008; Zhang et al., 2015; Yang et al., 2021).