FOXO1 and hepatocellular carcinoma: In previous studies, the close association of lower FOXO1 levels with human cancers such as hepatocellular carcinoma, colorectal cancer, pancreatic cancer, prostate cancer, and lung cancer have been demonstrated (Wu et al., 2012; Schwartz and Cote, 2016; Lou et al., 2017; Moeinifard et al., 2017).