However, some Dual PPARα/γ agonist such as compound 3q may accelerate atherosclerosis, it may related to the increase expression of the vascular endothelial activation and inflammation markers, such as P-selectin, MCP-1, VCAM-1, and CD36, that are also associated with plaque complexity (Calkin et al., 2007). Here, PPARA is linked to atherosclerosis.