PPARγ plays a crucial role in anti-atherosclerosis by promoting cholesterol efflux (Ozasa et al., 2011; Tsuboi et al., 2020), inhibiting monocytes infiltrating into the vascular intima under endothelial layer (Namgaladze et al., 2013), and inhibiting their transformation into macrophages (Zhang and Chawla, 2004; Charo, 2007; Oppi et al., 2020), inhibiting VSMCs proliferation and migration (Zhang et al., 2011; Durham et al., 2018). Here, PPARG is linked to atherosclerosis.