Deacetylation of PPARγ inhibits the cholesterol efflux PPARγ/LXRα/ABCA1 pathway (Cao et al., 2014; Yang et al., 2015), increased production of proinflammatory M1 macrophages and promotes the development of inflammatory response (Chen et al., 2008, 2010), leading to the onset and development of atherosclerosis. This evidence concerns the gene ABCA1 and atherosclerosis.