Importantly, iPLA2 is known to be elevated in the setting of obesity and has been shown to contribute to diet-induced weight gain, adipocyte hypertrophy and insulin resistance, via changes in fatty acid oxidation and mitochondrial content in vivo (Garces et al., 2010; Mancuso et al., 2010). Here, PLA2G6 is linked to obesity due to melanocortin 4 receptor deficiency.