Also, blood RBP4 levels were found to be negatively associated with indirect VLDL-apoB100 FCR and not significantly associated with direct VLDL-apoB100 FCR, suggesting that RBP4 is associated with more with VLDL dilapidation compared to direct uptake (Vergès et al., 2012), which may also explain the relationship between RBP4 and blood triglycerides in patients with type 2 diabetes. This evidence concerns the gene RBP4 and type 2 diabetes mellitus.