In support of these observations, the study by Lyoumi et al. on iron metabolism in Fechm1pas mice showed how a FECH deficiency leads to microcytic anemia, despite normal serum levels of iron, ferritin, and Hepcidin mRNA (Lyoumi et al., 2007). The gene discussed is FECH; the disease is hyperinsulinemic hypoglycemia, familial, 4.