In conclusion, LY294002 and rapamycin promoted expression of autophagy-related proteins LC3-II/I, p62, and beclin-1 through regulating PI3K/AKT/mTOR signalling pathway to resist the process of peritoneal fibrosis in vitro and in vivo (Figure 7). The gene discussed is BECN1; the disease is Peritoneal Fibrosis.