CRP and cancer: CRP is an acute-phase reactant synthesized in the liver that increases in inflammatory diseases [6], and when levels to 10 mg/L are usually thought to be clinically insignificant, levels of 100 mg/L and higher are considered to be associated with tissue necrosis [15,16]. Studies in the recent literature have shown that increased systemic inflammatory markers are associated with severity and poor prognosis with many types of diseases such as cancer [17], acute appendicitis [18], acute heart failure [19], and sepsis [20].