Of these polymorphisms, TAL1 rs2984618 was associated with a higher risk of depression (P = 1.79 × 10-4), and brain-derived neurotrophic factor (BDNF) rs1401635 was significantly associated with depression in an ethnic-dependent manner (OR = 0.88; 95% CI, 0.80-0.97; P = 0.01 in non-Europeans and OR = 1.11; 95% CI, 1.02-1.20; P = 0.02 in Europeans; P-interaction = 2.73 × 10-4) [84]. The gene discussed is BDNF; the disease is major depressive disorder.