LHB and major depressive disorder: Also, the yet unexplored LHb function in sleep appears relevant due to the relation between sleep and stress exposure (Goldstein and Walker, 2014; Vandekerckhove and Wang, 2018), and because sleep disturbances are key features of pathologies involving LHb dysfunction such as depression (Kudlow et al., 2013) and schizophrenia (Carruthers et al., 2021).