Having a more detailed comprehension of the LHb role in computing multimodal information regarding the emotional valence of a situation, prior stress experiences, and its contextual properties will likely help understanding some of the symptoms observed in pathologies associated with LHb dysfunctions such as depression (Li et al., 2013; Lecca et al., 2016; Nuno-Perez et al., 2018), addiction (Lecca et al., 2014; Velasquez et al., 2014; Mathis and Kenny, 2019) frontotemporal dementia (Bocchetta et al., 2016), and possibly schizophrenia (Zhang et al., 2017; Schafer et al., 2018). This evidence concerns the gene LHB and depressive disorder.