P2RX7 and Sjogren syndrome: Research has found that the number of purinergic receptors P2Y1, P2Y11, and P2Y13 in lacrimal gland MEC (myoepithelial cells) of TSP1-/- mice (a mouse model of Sjögren's syndrome) decreased significantly, and the regulatory ability of cholinergic agonists, VIP, and purinergic receptors decreased, accompanied by increased expression of inflammatory factors (94).