The toxicity analysis showed that Anxa3, Cd14, Cd44, Lcn2, Umod, Dpysl3, hepatitis A virus cellular receptor 1 (Havcr1), Hp, Serpina3, and Lgals1 were responsible for acute renal failure (AKI), persistent renal ischemia-reperfusion injury, positive acute phase response proteins and increasing the transmembrane potential of mitochondria and mitochondrial membrane (Table 2). Here, SERPINA3 is linked to acute kidney injury.