STRING analysis of the regulatory relationship found that 3 ROS-related genes (NQO1, TXNRD1, and PRDX4) can be repaired by the DNA repair gene NEIL3 and other DNA repair genes.A large amount of evidence showed that NQO1 has a “Janus” effect in cancer biology, playing a role in suppressing cancer and promoting tumors (26). The gene discussed is PRDX4; the disease is cancer.